World Journal of Medical and Surgical Case Reports Volume No 8

Review Open Access

Diaphragm Disease: Unique Small Intestinal Pathology Associated with Non-Steroidal Anti-Inflammatory Drugs (NSAID) – A Case Report with Review of Literature

Dr. Mona Bargotya, Dr. Seema Sachan and Dr. Ankita Mehta
World Journal of Medical and Surgical Case Reports 2018, 7:5


Nonsteroidal anti-inflammatory drugs(NSAIDs) induce a spectrum of intestinal lesions in which diaphragm disease (DD) is a rare occurrence, which usually occurs after consuming these drugs for prolonged periods. Nonspecific clinical features and vague symptoms makes difficult to diagnose this disease clinically as well as by radiological investigations. Hence, it is quite difficult to differentiate DD from small intestinal tumours and inflammatory bowel disease. The diagnosis is made on final histopathology after surgical resection and anastomosis of the affected segment which is the approved treatment. Herein, we report a case of diaphragm disease presenting with sub-acute intestinal obstruction with characteristic gross and histological pathognomonic findings.


Diaphragm disease (DD), Nonsteroidal anti- inflammatory drugs (NSAIDs)

Download PDF    Full Text