Case Report

Anal canal gastrointestinal stromal tumour (GIST) – A rare primary location

Laranjeira Ânia, Patrício Joana, Senhorinho Rogério and Caravana Jorge
World Journal of Medical and Surgical Case Reports 2018, 7:2

Abstract

Background

A gastrointestinal stromal tumour (GIST) is a mesenchymal neoplasm that can arise in any part of the digestive tract. Anorectal location represents 5 to 10% of all GISTs and nearly 2 to 8% of anorectal GISTs arise from the anal canal.

Case Presentation

A 75-year-old woman was referred to our Institution due to a perianal mass that was growing in the last two years. A pelvic MRI documented a large mass in the intersphincteric space of well-defined limits with central necrosis. A local excision was undertaken while preserving sphincter function, since the mass showed well circumscribed limits without invasion. The histological diagnosis of high-risk GIST was made. The patient completed 3 years of adjuvant chemotherapy with Imatinib and has had 5 years of follow-up without local recurrence or distant metastases.

Conclusions

The objectives of sphincter preservation and optimal quality of life must be weighed against the risks that are associated with the highly variable recurrence behaviour of anorectal GISTs.

Keywords

Gastrointestinal stromal tumour, anal canal, KIT gene

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