World Journal of Medical and Surgical Case Reports Volume No 8

Case Report Open Access

Spontaneous Bone Regeneration after Resection of an Unusually Aggressive Recurrent Central Giant Cell Granuloma in a Nigerian Adolescent

Olufemi Ogundipe, Oluwafemi Ariyibi, Ayodeji Egberongbe and Gb Akinwonmi
World Journal of Medical and Surgical Case Reports 2017, 6:2



Aggressive variant of Central Giant Cell granuloma (CGCG) is rare and is characterized by the presence of pain, rapid growth, expansion and / or perforation of the cortex, and a high tendency to recur based on clinical and radiographic findings. It account for about a third of all cases of CGCG.

Case Presentation

A case of aggressive CGCG with early recurrence, rapid growth associated with pain and spontaneous bleeding is presented. Spontaneous bone regeneration with no evidence of recurrence was noted after 2.5 year follow-up. The factors responsible for spontaneous bone regeneration (SBR) are discussed.


This case illustrates the need for radical surgery in aggressive CGCG. High osteogenic potential in a growing mandible offers the possibility of bone regeneration.

Key words

Spontaneous bone regeneration, aggressive central giant cell granuloma, case report.

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