World Journal of Pathology Volume No 8

Case Report Open Access

Generalized lymphadenopathy including supraclavicular lymph node involvement: A rare presentation of urothelial bladder carcinoma. A case report with Fine-Needle Aspiration Cytology and review of the literature.

Maounis Nicoletta, Almpanis Zannis, Chorti Maria, Mantzouranis Constantinos, Delamarinis Konstantinos, Tsiafaki Xanthi, Demonakou Maria and Ellina Eleni
World Journal of Pathology 2017, 6:7



Urothelial carcinoma of the bladder typically metastasizes to the regional lymph nodes and to visceral sites including bones, lung and liver. Metastasis to supraclavicular lymph nodes is extremely rare.

Case Presentation

We describe a 62-yr-old female with a rare manifestation of disseminated urothelial bladder cancer, with an extensive nested component, who presented with generalized lymphadenopathy. This clinical picture would be most compatible with a malignant lymphoma. The primary diagnostic approach was fine-needle aspiration cytology performed on a palpable mass on the left supraclavicular region.


Fine-needle aspiration cytology, in conjunction with immunocytochemistry, can successfully guide the clinicians to identify the primary site of a neoplasm, especially in unusual cases such as ours.

Key Words

FNAC, Urinary bladder, Urothelial carcinoma, nested, Supraclavicular lymph node, Metastasis

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