World Journal of Medical Research Volume No 8

Research Open Access

Importance of bcl2 Protein Expression in Histological Negative Margins after Excision of Oral Squamous Cell Carcinoma

Manoj Pandey, Devendra K Ravi, Mridula Shukla and Mohan Kumar
World Journal of Medical Research 2017, 6:1



B cell lymphoma-2 (bcl-2) is an intercellular membrane associated protein that functions as anti apoptotic protein via mitochondria mediated intrinsic pathway of caspase activation. We evaluated expression of bcl2 protein in patients with oral cancer and in adjacent normal tissue.

Patients and methods

Bcl-2 protein expression was evaluated in patients with oral cancer undergoing surgical resection using immunohistochemistry (IHC) in the tumour tissue and the adjacent normal tissue.


Bcl2 protein expression was not seen in any tumour tissue however, in the normal margin 61 cases showed bcl2 expression. This expression was cytoplasmic in all the cases.


This expression in margins correlated with lymphatic spread of the disease and suggest poor prognosis in this subset of the patients. The mRNA expression, polymorphism, mutations, SNP’s were not looked at in the present study and hence, the exact significance of the results is not clear.

Key words

apoptosis; oral cancer; tongue; buccal mucosa; alveolus; lymph node

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