World Journal of Medical Research Volume No 8

Original Article Open Access

Study of Immunohistochemistry and Aggressiveness of Non-functioning Pituitary Adenomas (Implication on Management): A case series of 30 cases.

Manash Bora, Radhey Shyam Mittal, Shashi Singhvi and Achal Sharma
World Journal of Medical Research 2015, 4:1



Pituitary adenomas are the third most common brain tumor comprising 10-20% of primary brain tumors and nearly 25% are non functioning pituitary adenoma (NFPA). NFPA are larger tumors and many of them are invasive and tend to recur or regrow. Regarding management of NFPA there is no clear common consensus for indication of adjuvant therapies.

Study Design

A prospective study of clinically non-functioning pituitary adenoma cases operated in our institute from June 2013 to May 2014 were done.

Patients and Methods

Clinical data of patients, biochemistry, radiology, per-operative findings, histopathology, and immunohistochemistry(IHC) with proliferative index KI-67/MIB are analyzed and their correlation with biological aggressiveness is searched for.


Total 30 cases were studied. Majority of them are found to have cells positive for LH/FSH (36.66%), and prolactin (PRL) (16.66%), ACTH (6.66%), GH (6.66%), Pleurihormonal (23.33%). In 10% tumors no hormone cell was positive hence termed Null cells. Radiological invasiveness was found in66.66% (20/30) cases and 30% of them had high KI-67.


KI-67/MiB and its relation with invasiveness of tumor, certain HPE type & Hormone markers may be key in understanding biological behavior of NFPAs &selection of patients for strict follow-up and adjuvant radiotherapy.

Download PDF    Full Text