World Journal of Surgical Medical and Radiation Oncology Volume No 9

Case Report Open Access

Combined treatment extraskeletal Ewing sarcoma of the seminal vesicle: Case report and literature review

Mariya Berkut, Alexander Nosov, Anna Artemyjeva, Vladimir Kushnarev and Sergey Reva
World Journal of Surgical Medical and Radiation Oncology 2020, 9:1



Exceptional sites of occurrence of extraskeletal Ewing’s sarcoma/PNET include several organs of the genitourinary system. The Ewing’s sarcoma/PNET is an extremely rare prostate and seminal vesicle sarcoma. Such lesions are often overlooked in the differential diagnosis of pelvic masses. The purpose of this article reports the case of an extraskeletal Ewing’s seminal vesical sarcoma (EESVS) and to conduct a literature review on the topic (literature review was done using the PubMed/Medline databases up to June 2018).

Case presentation

A 35-year old male complained about chronic pain in the lower left quadrant of the abdomen. Magnetic resonance imaging (MRI) revealed a massive tumor surrounding the left seminal vesicle with no metastatic lesions (on PET-CT). Prostate and tumor biopsy with subsequent immunohistochemical analysis (IHC) revealed changes specific to Ewing's sarcoma. Neoadjuvant chemotherapy 6 cycles were performed with partial response before surgical treatment followed by laparoscopic vesicalectomy with resection of the left ureter and bladder wall.


Neoadjuvant chemotherapy followed by surgical resection of EESVS is considered as the best treatment approach in such clinical situations according to literature review.


sarcoma, seminal vesicle, Extraskeletal Ewing’s sarcoma, small round cell tumors.

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