World Journal of Pathology Volume No 10

Original Article Open Access

Histopathological Spectrum of Lesions in Gastrointestinal Endoscopic Biopsies: A Retrospective Study in A Tertiary Care Center

Veenaa Venkatesh and Riyana R Thaj
World Journal of Pathology 2019, 8:1



Lesions of Gastrointestinal tract (GIT) are commonly seen in the surgical department patients. These patients are subjected to endoscopic examination and biopsy is taken for further evaluation. Both upper and lower parts of gastrointestine can be accessed through endoscopy. A wide spectrum of lesions occurs in the whole of GIT. This study is done to statistically analyse the various histopathological lesions and to evaluate the usefulness of endoscopic biopsy to the clinicians for effective management.

Study design

A total of 180 cases received in the histopathology lab were analysed.

Materials and methods

All endoscopic biopsies from upper and lower GIT were received and processed. Paraffin blocks were made and sections were cut at 4 micron thickness and stained with routine Hematoxylin and Eosin stain.


Out of total 180 endoscopic biopsies, the most commonly encountered were gastric biopsies, accounting to 103 cases, followed by colon-rectum (40), esophagus, duodenum and ileum. Malignancy was the most common lesion in the esophagus, chronic non-specific gastritis was the most common lesion in stomach. Among the malignant cases, esophagus was found to be the most common site, followed next by stomach.


Hence in this study, various non-neoplastic and neoplastic lesions were found in the whole of GIT. This study is done to emphasize the usefulness of endoscopic biopsy in diagnosing the conditions, thus helping the surgeons to decide further management prior to resection, especially in malignant cases.


Gastro-intestinal lesions, endoscopy, malignancy, non-neoplastic lesions.

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